The Double Marker Test is a prenatal screening test that helps assess the risk of chromosomal abnormalities in an unborn baby. Typically recommended during the first trimester of pregnancy, this test is crucial for early detection of conditions like Down syndrome, Edwards syndrome, and Patau syndrome. It is a non-invasive test and is often performed between the 11th and 14th week of pregnancy as part of the first-trimester screening process.
What Is a Double Marker Test?
The Double Marker Test is a blood test that measures the levels of two important markers in the mother’s blood:
- Free Beta-hCG (human chorionic gonadotropin)
- PAPP-A (Pregnancy-Associated Plasma Protein A)
These markers, when combined with the findings of a nuchal translucency (NT) scan from an ultrasound, help determine the likelihood of chromosomal abnormalities in the fetus.
This test does not confirm any disorder but only indicates the level of risk, helping doctors decide whether further diagnostic testing is necessary.
Why Is the Double Marker Test Important?
The main purpose of the Double Marker Test is early risk assessment. It provides critical information to parents and doctors, allowing informed decisions about additional testing or early interventions if necessary. The test is particularly recommended for:
- Women above 35 years of age
- Those with a family history of genetic disorders
- Pregnancies through IVF or assisted reproductive techniques
- Previous pregnancy with chromosomal abnormalities
The test offers a safer alternative to invasive tests like amniocentesis or chorionic villus sampling (CVS), which carry a small risk of miscarriage.
How Is the Double Marker Test Done?
The process is simple and quick:
- Blood Sample Collection – A small amount of blood is drawn from the mother’s arm.
- Ultrasound (NT Scan) – This is usually done separately to measure the fluid at the back of the baby’s neck (nuchal translucency).
- Combined Assessment – The blood test results and NT scan are combined using specialized software to assess the overall risk.
You don’t need to fast before this test, and it is completely safe for both mother and baby.
What Is the Normal Range of a Double Marker Test?
The test report categorizes results into three risk levels:
- Low Risk – No further testing may be required.
- Moderate Risk – Your doctor might suggest additional screening.
- High Risk – Diagnostic tests like NIPT, CVS, or amniocentesis may be advised.
The exact numerical values for beta-hCG and PAPP-A vary depending on gestational age and lab standards. Always consult your doctor to interpret the results correctly.
Double Marker Test Price in India
The cost of the Double Marker Test in India typically ranges from ₹2,500 to ₹4,000, depending on the location, diagnostic center, and whether the NT scan is included.
Popular diagnostic labs such as Thyrocare, Metropolis, Apollo Diagnostics, and Dr. Lal PathLabs offer this test in most cities.
Final Thoughts
The Double Marker Test plays a key role in prenatal care by offering early insights into the baby’s health. While it doesn’t provide a definitive diagnosis, it helps expectant parents take proactive steps. Always discuss the results with your gynecologist or genetic counselor to understand the implications and the next steps.
